Publications by authors named "Antonino Natoli"
Article Synopsis
- Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that affects AAT levels and is linked to respiratory diseases like COPD, bronchiectasis, and asthma; this study aimed to identify cases of AATD in Turkish patients with these conditions.
- The study included 1,088 patients, mostly with COPD, and found that 5% had AATD mutations, with a mix of common and rare mutations identified.
- The research concluded that AATD mutations are a significant genetic factor contributing to lung disease in the studied population, highlighting the need for awareness and genetic testing among patients with respiratory symptoms.
Hodgkin/Reed-Sternberg lymphoma (HL) is a clonal B-cell-related malignancy. Although many patients with HL can be cured by the current regimen of high-dose multi-agent chemotherapy, the treatment causes high risks of later pathologies including secondary malignancies. This fact highlights the demand to develop rational treatment for HL.
View Article and Find Full Text PDFA quick and efficient synthesis and the biological evaluation of promising antitumor-antibiotics proximicins A, B and C are reported. The characteristic repetitive unit of these molecules, the methyl 4-Boc-aminofuran-2-carboxylate 15, was prepared in three synthetic steps in good yield using an optimised copper-catalysed amidation method. The proximicins were evaluated for their antitumor activity using cellular methods.
View Article and Find Full Text PDFA 48 kDa acidic and putative calcium-binding glycoprotein was isolated from pearls of the freshwater mussel Hyriopsis cumingii. This protein was compared with a related 46 kDa polypeptide, obtained from the nacreous shell of the same species. Separation by two-dimensional gel electrophoresis revealed that the difference in molecular weight is due to the higher extent of glycosylation of the 48 kDa protein existing in pearls.
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