Publications by authors named "Antonina Y Shevchenko"
Eur J Endocrinol
August 2004
Article Synopsis
- Agouti protein (AP) and agouti-related protein act as antagonists to melanocortin receptors, impacting the hypothalamo-pituitary-adrenal (HPA) axis and are involved in obesity profiles seen in agouti yellow (A(y)) mice.
- The study compared HPA function in two groups of 3-month-old male C57Bl/6J mice with differing agouti genotypes (A(y)/a and a/a) using various stress stimuli to assess HPA response.
- Results indicated that AP overexpression enhances HPA axis responses to stress independent of obesity; A(y)/a mice showed greater adrenal responsiveness to ACTH and improved stress-induced feedback inhibition with dexamethasone compared to a/a mice
