PECULIARITIES OF MOTOR ACTIVITY OF RATS IN SIMULATION PHARMACOLOGICAL DEPRESSOGENIC STATES.

Objective: The aim: To analyze and compare the features of changes in the motor activity of rats on the background of pharmacological models of depressive disorders.

Patients And Methods: Materials and methods: Depressive-like state was simulated on 40 mature male Wistar rats using: reserpine (15 mg/kg), clonidine (0.1 mg/kg), haloperidol (0.

Anhedonia at experimental models of chronic stress and its correction.

Introduction: Different types of chronic stress lead to neurotic and depressive disorders. Key symptoms of these disorders are anhedonia and correction of which will indicate the efficacy of proposed therapy. The aim of the paper is to investigate the influence of amide 2-hydroxy-N-naftalen-1-il-2-(2-oxo-1,2-dihidro-indole-3-iliden) and ethyl ether 4-[2-hydroxy-2-(2-oxo-1,2-dihidro-indole-3-iliden)-acetamin]-butyric acid on anhedonia after the experimental neurosis and chronic moderate stress in rats.