Publications by authors named "Antonina Kazantseva"
Article Synopsis
- Maternal diet and obesity influence the taste preferences and obesity risk in offspring, but the specifics of how maternal obesity affects these outcomes are not well understood.
- In a study with mice, it was found that while obese mothers had higher metabolic markers, their offspring did not show changes in food choice or obesity risk when consuming a sweet-fat diet (SFD).
- Overall, when obese mothers followed a standard diet, their obesity did not significantly impact the offspring's dietary choices or susceptibility to diet-induced obesity.
Article Synopsis
- FGF21 shows potential as a treatment for obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), but its effects vary between male and female mice with mutations impacting melanocortin receptors.
- A study found that female mice had higher obesity rates and different metabolic responses compared to males after FGF21 treatment, indicating sex plays a role in how FGF21 affects metabolism.
- While FGF21 increased food intake and activity in both sexes, it only improved metabolic issues like hyperinsulinemia and liver fat in male mice, suggesting the treatment's benefits are more significant for males.
Article Synopsis
- * Female mice showed a stronger preference for high-fat diets, less body fat, and more favorable blood parameters than males, indicating potential sex-based differences in obesity development.
- * FGF21 treatment reduced fat accumulation and improved metabolic markers in both sexes, but it specifically induced beneficial gene expression changes in the female mice's white adipose tissue.
C57Bl mice exhibit impaired glucose metabolism by the late adult age under standard living conditions. The aim of this study was to evaluate white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle expression of genes involved in carbohydrate-lipid metabolism at postpubertal stages preceding the late adult age in C57Bl mice. Muscle mRNA levels of uncoupling protein 3 () and carnitine palmitoyltransferase 1 () (indicators of FFA oxidation), WAT mRNA levels of hormone-sensitive lipase () and lipoprotein lipase () (indicators of lipolysis and lipogenesis), muscle and WAT mRNA levels of the type 4 glucose transporter (indicators of insulin-dependent glucose uptake), and BAT mRNA levels of uncoupling protein 1 () (indicator of thermogenesis) were measured in fed and 16 h-fasted mice in three age groups: 10-week-old (young), 15-week-old (early adult), and 30-week-old (late adult).
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