Influence of specific immunotherapy on the activity of human T lymphocyte Kv1.3 voltage-gated potassium channels in insect venom allergic patients.

Kv1.3 channels play an important role in T lymphocytes function. CD4(+) and CD4(+)CD25(+) T cells are two broad categories of T cells that are critically involved in the immunoresponse to allergens and that are also a major target for allergen immunotherapy.

[The conductivity of potassium ion channels in lymphocytes T of patients with pollinosis].

Ion channels, as integral membrane protein structures controlling a passive ion transport across cell membranes, contribute importantly to cellular signaling processes. The voltage gated potassium channels Kv1.3 within the membranes of lymphocyte T take part of physiological reactions in these cells.