Publications by authors named "Antonietta Raffaella Maria Sabbatini"
Article Synopsis
- Researchers created a 3D model of the thyroid gland to study how different substances, like 3-MNT, affect thyroid cells better than flat 2D cultures.
- They tested the model using special techniques to see how the cells looked and how well they worked, finding that the 3D structure behaved more like real thyroid tissue.
- The study found that 3MNT changed the activity of a specific thyroid enzyme and affected the production of important proteins, making the 3D model a useful tool for understanding thyroid health.
Mesencephalic cell cultures are a good model to study the vulnerability of dopaminergic neurons and reproduce, in vitro, experimental models of Parkinson's disease. Rotenone associated as an environmental neurotoxin related to PD, is able to provoke dopaminergic neuron degeneration by inhibiting complex I of the mitochondrial respiratory chain and by inducing accumulation of α-synuclein. Recently, rotenone has been described to activate RhoA, a GTPase protein.
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