Monkeypox virus infection mimicking primary syphilis.

In our case series of monkeypox (MPX) virus infected patients, one had a single genital ulcer as the only cutaneous manifestation of the infection. Physical examination revealed a single, rounded ulcer of the shaft penis characterized by pinkish raised, infiltrated borders and a crusty yellowish bottom associated with bilateral inguinal lymphadenopathies. Serology for infection and a complete screening for sexually transmitted infections (STIs) resulted negative except for the detection of at the cultural examination and MPX DNA at the ulcer bottom.