Publications by authors named "Antonia Vogt"
Tissue engineering and cell therapy for regenerative medicine have great potential to treat chronic disorders. In musculoskeletal disorders, mesenchymal stromal cells (MSCs) have been identified as a relevant cell type in cell and regenerative strategies due to their multi-lineage potential, although this is likely to be a result of their trophic and immunomodulatory effects on other cells. This PRISMA systematic review aims to assess whether the age of the patient influences the chondrogenic potential of MSCs in regenerative therapy.
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- The study aimed to assess if a daily goal checklist affects the length of stay (LOS) in the pediatric cardiac intensive care unit (PCICU) after heart surgery.
- The STANDARD group had a median LOS of 96 hours, while the control group had 101.5 hours, showing no statistically significant difference.
- Key factors influencing prolonged LOS included age, severity of congenital heart disease (CHD), and certain clinical scores, indicating that structured goal management benefits recovery post-surgery.
The use of mesenchymal stromal cells (MSCs) in regenerative medicine and tissue engineering is well established, given their properties of self-renewal and differentiation. However, several studies have shown that these properties diminish with age, and understanding the pathways involved are important to provide regenerative therapies in an ageing population. In this PRISMA systematic review, we investigated the effects of chronological donor ageing on the senescence of MSCs.
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