The discovery of the church of Rungholt, a landmark for the drowned medieval landscapes of the Wadden Sea World Heritage.

The UNESCO World Heritage Wadden Sea holds remains of a medieval cultural landscape shaped by interactions between man and natural forces. From the Netherlands to Denmark, human efforts of cultivating low-lying areas created a unique coastal landscape. Since the Middle Ages, storm floods widely drowned embanked cultural land and especially affected North Frisia (Germany), where once fertile marshland was permanently turned into tidal flats.

Increased TIM-3 and galectin-9 serum levels in patients with advanced systemic mastocytosis.

Background: Systemic mastocytosis is characterized by expansion of clonal mast cells in various tissues. Several biomarkers with diagnostic and therapeutic potential have recently been characterized in mastocytosis, such as the serum marker tryptase and the immune checkpoint molecule PD-L1.

Objective: We aimed to investigate whether serum levels of other checkpoint molecules are altered in systemic mastocytosis and whether these proteins are expressed in mastocytosis infiltrates in the bone marrow.