The difference between cystatin C- and creatinine-based assessment of kidney function in acute heart failure.

Aims: Acute heart failure (HF) is associated with muscle mass loss, potentially leading to overestimation of kidney function using serum creatinine-based estimated glomerular filtration rate (eGFR ). Cystatin C-based eGFR (eGFR ) is less muscle mass dependent. Changes in the difference between eGFR and eGFR may reflect muscle mass loss.