Publications by authors named "Antonia Heymans"
Papillary thyroid carcinoma (PTC), the most common malignancy of follicular cell derivation, is generally associated with good prognosis. Nevertheless, it is important to identify patients with aggressive PTCs and unfavorable outcome. Molecular markers such as BRAF mutation and TERT promoter mutations have been proposed for risk stratification.
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- The study aimed to connect the genetic mutations in papillary thyroid carcinoma with the aggressiveness of the disease to improve surgical treatment recommendations.
- The analysis included 171 patients, revealing a notable prevalence of BRAF-V600E mutations and significant correlations between certain mutations and adverse clinical outcomes, such as increased risk of distant metastasis and radioiodine-refractory disease.
- Findings suggest that patients with both BRAF and TERT promoter mutations should be considered for more aggressive treatment strategies, while RET rearrangements were linked to more lymph node involvement but did not impact metastasis or radioiodine resistance.