Publications by authors named "Antonia C Hardcastle"

Article Synopsis
  • Dietary modifications can influence inflammatory processes and aid in the prevention of chronic diseases, particularly in postmenopausal women.
  • A longitudinal study of Scottish postmenopausal women revealed that a 'prudent' dietary pattern—high in fish, yogurt, and fruits—was linked to lower levels of inflammatory biomarkers like hs-CRP and IL-6.
  • Conversely, a 'meat-dominated' dietary pattern showed an increase in inflammatory markers, indicating that diet plays a significant role in managing inflammation and chronic disease risk.
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Background: little is known about changes in the quality of medical care for older adults over time.

Objective: to assess changes in technical quality of care over 6 years, and associations with participants' characteristics.

Design: a national cohort survey covering RAND Corporation-derived quality indicators (QIs) in face-to-face structured interviews in participants' households.

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Osteoporosis and fragility fractures are a growing problem for our aging population with around 1 in 2 women and 1 in 5 men suffering from an osteoporotic fracture during their lifetime. Although there are established factors that can reduce the risk of fracture such as maintaining physical activity, ceasing smoking, and adequate vitamin D status, and intakes of calcium; dietary mechanisms are less well established. The relevance of the flavonoid group of bioactive compounds found in fruits and vegetables has been less investigated.

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Background: Silicon (Si), as Si(OH)(4), is derived mainly from plant-based foods. Dietary Si is associated with bone mineral density (BMD) in premenopausal but not postmenopausal women.

Objective: To examine the association between Si intake and markers of bone health in middle-aged women and to test for interaction with oestrogen status.

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Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of perimenopausal Scottish women. Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study.

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Trials in free-living populations involving increased consumption of fruit and vegetables are difficult to monitor. We evaluated biomarkers for assessing fruit and vegetable intake and compliance in a 2-year trial. Postmenopausal women were randomised to 300 g additional fruit and vegetables per d (n 66), placebo (n 70) or potassium citrate (n 140).

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Background: Alkali provision may explain why fruit and vegetables benefit bone health.

Objective: We aimed to determine the effects of alkali-providing potassium citrate (double-blind) and fruit and vegetable intake (single-blind) on bone turnover over 2 y.

Design: We conducted a randomized placebo-controlled trial in 276 postmenopausal women (aged 55-65 y).

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