Fecal microbiota transplantation in a patient with chronic diarrhea and primary and secondary immunodeficiency (common variable immunodeficiency and splenectomy).

The gut microbiota serves a crucial role in the development of host immunity. Immunocompromised patients are particularly vulnerable to dysbiosis not only by virtue of a defect in the immune system but also due to increased susceptibility to infection and multiple courses of antibiotic therapy. Fecal microbiota transplantation is by far the most effective option for restoring gastrointestinal homeostasis.

ConsensuSV-ONT - a modern method for accurate structural variant calling.

The improvements in sequencing technology make the development of new tools for the detection of structural variance more and more common. However, the tools available for the long-read Oxford Nanopore sequencing are limited, and it is hard to choose one, which is the best. That is why there is a need to create a tool based on consensus that combines existing work in order to discover a set of high-quality, reliable structural variants that can be used for further downstream analysis.