Publications by authors named "Antonello Pinna"
Article Synopsis
- Researchers explored how cerebral mitochondrial and hemodynamic issues might affect patients with Bipolar Disorder (BD) by assessing oxygen levels in the brain using MRI and Methylene Blue (MB) as a treatment.* -
- In an experiment with 15 BD patients and 15 healthy controls, participants underwent MRI scans after receiving either MB or a placebo, revealing significant decreases in brain oxygen metabolism in BD patients compared to controls.* -
- Findings suggest that BD patients demonstrate a unique neurometabolic response to MB, indicating their increased vulnerability to metabolic stress and potentially opening doors for new therapeutic approaches.*
The neurobiological bases of mood instability are poorly understood. Neuronal network alterations and neurometabolic abnormalities have been implicated in the pathophysiology of mood and anxiety conditions associated with mood instability and hence are candidate mechanisms underlying its neurobiology. Fast-spiking parvalbumin GABAergic interneurons modulate the activity of principal excitatory neurons through their inhibitory action determining precise neuronal excitation balance.
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