Publications by authors named "Antonelli Rita"
Article Synopsis
- Periodontal diseases like gingivitis and periodontitis are common, with gingivitis being a mild inflammation caused by plaque buildup.
- Salivary diagnostics are gaining traction as saliva composition changes with health issues, prompting research into its potential to indicate early signs of gingivitis.
- A study using H-NMR spectroscopy analyzed saliva from healthy individuals, aiming to identify specific metabolites linked to early gingival inflammation, suggesting a potential method to distinguish between normal and early disease states based on saliva analysis.
The activity of dental caries, combined with its multifactorial etiology, alters salivary molecule composition. The present systematic review was developed to answer the following question: "Are salivary biomarkers reliable for diagnosis of dental caries?". Following the "Preferred Reporting Item for Systematic Reviews and Meta-analysis" (PRISMA) guidelines, the review was conducted using multiple database research (Medline, Web of Science, and Scopus).
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- Saliva is a promising resource for identifying health biomarkers because it reflects an individual's health status and has molecular links to blood due to the salivary glands' high vascularization.
- This study investigated the relationships between metabolite profiles in saliva and serum using samples from 20 healthy young individuals, employing advanced H-NMR spectroscopy and statistical analyses.
- Findings indicate that while there are correlations between serum and saliva metabolites, saliva's complex composition and oral metabolism mean it cannot be seen as merely a filter of blood, highlighting its importance for laboratory diagnostics.
Background: Acute myocardial infarction (AMI) accounts for about 7 million deaths per year worldwide. The early identification of signs and symptoms and the detection of specific serological markers of this disease are mandatory to reach a prompt diagnosis and begin potentially life-saving treatment. Point-of-care technologies applied to salivary diagnostics can provide rapid, simple, low-cost, and accurate measurements of specific markers and can also be used in emergency settings.
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- This study investigates the metabolic composition of saliva to find non-invasive diagnostic biomarkers for oral health, focusing on submandibular/sublingual saliva, which has not been thoroughly analyzed before.
- Researchers analyzed saliva samples from 20 healthy individuals using nuclear magnetic resonance and identified varying metabolites present in different saliva types: whole, parotid, and submandibular/sublingual.
- The findings revealed specific metabolites unique to each saliva subtype and laid the groundwork for further research into salivary biomarkers related to oral and systemic health issues.