Publications by authors named "Antonella Pomilio"
Article Synopsis
- - Shwachman-Diamond syndrome (SDS) is a common inherited bone marrow failure condition characterized by low bone marrow cellularity and a significant risk of developing blood disorders, including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) at a young age.
- - Most patients with SDS carry a specific nonsense mutation in the SBDS gene, and recent research shows that the drug ataluren can successfully restore functional SBDS protein in these patients' bone marrow stem cells.
- - The study also identified a new drug analogue, NV848, which not only restores SBDS protein synthesis with low toxicity in zebrafish but also enhances neutrophil maturation and reduces abnormal cell development, indicating potential for
An excessive, non-resolving inflammatory response underlies severe COVID-19 that may have fatal outcomes. Therefore, the investigation of endogenous pathways leading to resolution of inflammation is of interest to uncover strategies for mitigating inflammation in people with SARS-CoV-2 infection. This becomes particularly urgent in individuals with preexisting pathologies characterized by chronic respiratory inflammation and prone to bacterial infection, such as cystic fibrosis (CF).
View Article and Find Full Text PDFProresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review.
Stem Cells Transl Med
October 2019
Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lipid mediators (SPMs) are small lipids formed by the enzymatic metabolism of polyunsaturated fatty acids.
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