Publications by authors named "Antonella Gentile"

Article Synopsis
  • The study aimed to analyze the clinical characteristics and gastric tumor risk in patients with autoimmune gastritis (AIG) across eight Italian hospitals, focusing on those with and without Helicobacter pylori infection.
  • A total of 1,598 AIG patients were assessed; findings indicated that those who were H. pylori-naive had a higher tendency for certain autoimmune conditions and significant family health history.
  • The overall incidence of gastric adenocarcinoma was low, but a notable percentage developed type 1 gastric neuroendocrine neoplasm (gNEN), especially in patients presenting with vitamin B12/iron deficiencies, suggesting these individuals should receive closer monitoring.
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Introduction: Diverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.

Methods: Adult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved.

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Introduction: The natural history of autoimmune gastritis (AIG) has been poorly described. In this study, we report the long-term natural history and clinical clustering of the full spectrum of AIG, from the potential to the complicated stage.

Methods: Prospective single-center study conducted in a tertiary referral center.

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Article Synopsis
  • The study investigates the diagnostic delays in patients with symptomatic uncomplicated diverticular disease (SUDD) and identifies associated risk factors over a period from 2010 to 2022.
  • A total of 70 patients were analyzed, revealing a median diagnostic delay of 7 months, with 25% initially misdiagnosed with irritable bowel syndrome (IBS).
  • Key findings indicated that past misdiagnosis, high educational levels, and prior abdominal surgeries significantly influenced the extent of diagnostic delays in SUDD cases.
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Glutathione is a tripeptide synthesized at cytosolic level, that exists in cells in a reduced form (thiol-reduced-GSH-) and in an oxidized form (disulfide-oxidized). The antioxidant function of GSH has led to speculation about its therapeutic role in numerous chronic diseases characterized by altered redox balance and reduced GSH levels, including, for instance, neurodegenerative disorders, cancer, and chronic liver diseases. Among these latter, non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in hepatocytes, in the absence of alcohol abuse or other steatogenic factors, is one of the most prevalent.

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  • Autoimmune diseases (AIDs) are on the rise and include over 100 different types, causing significant global health issues; early detection is crucial for effective treatment.
  • Autoantibodies are typically present in patients with AIDs and help with diagnosis, but some patients (seronegative AIDs) may lack these antibodies, complicating diagnosis.
  • The review explores reasons for seronegativity and discusses diagnostic challenges and management strategies for various AIDs, such as rheumatoid arthritis and autoimmune thyroid diseases.
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  • A study investigated the presence of intraepithelial lymphocyte (IEL) infiltration in patients with potential autoimmune gastritis (AIG) who had positive anti-parietal cell antibodies but no gastric atrophy.
  • Nine patients who developed overt AIG were analyzed for deep and superficial CD3+ IEL counts, revealing significantly higher deep IEL counts compared to healthy controls and those with active H. pylori gastritis.
  • Results suggest that increased deep CD3+ IEL infiltration could serve as a marker for potential AIG, indicating the need for further studies with more patients to confirm these findings.
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Few conflicting data are currently available on the risk of SARS-CoV-2 infection in patients with autoimmune disorders. The studies performed so far are influenced, in most cases, by the treatment with immunosuppressive drugs, making it difficult to ascertain the burden of autoimmunity per se. For this reason, herein we assessed the susceptibility to COVID-19 in immunosuppressive drug-naïve patients with autoimmune diseases, such as autoimmune gastritis (AIG), celiac disease (CD), type 1 diabetes (T1D), and autoimmune thyroid disease (AITD).

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Recent studies support the hypothesis that microbes can seed some Alzheimer's disease (AD) cases, leading to inflammation and overproduction of amyloid peptides. (Pg) is a keystone pathogen of chronic periodontitis and has been identified as risk factor for the development and progression of AD. The present preliminary study aimed to quantify Pg abundance in neurodegenerative disease (ND) patients compared with neurologic patients without neurodegenerative disorders (no-ND) and healthy controls (HC) to determine possible association between Pg abundance and neurodegenerative process.

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COVID-19 patients typically present with lower airway disease, although involvement of other organ systems is usually the rule. Hematological manifestations such as thrombocytopenia and reduced lymphocyte and eosinophil numbers are highly prevalent in COVID-19 and have prognostic significance. Few data, however, are available about the prevalence and significance of anemia in COVID-19.

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Background: Autoimmune atrophic gastritis (AAG) is an immune-mediated disorder characterised by destruction of gastric oxyntic mucosa AIM: To explore gastric histopathological evolution in a cohort of AAG patients over a prolonged follow-up METHODS: Single centre prospective study enrolling consecutive patients with histologically confirmed AAG between 2000 and 2018. All AAG patients undergoing endoscopic follow-up every 1-3 years were classified as having stages 1, 2 or 3 according to atrophy severity (mild, moderate and severe). AAG patients with either glandular or neuroendocrine dysplasia/neoplasia were classified as having stage 4.

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Due to their peculiar qualities, metal-based nanostructures have been extensively used in applications such as catalysis, electronics, photography, and information storage, among others. New applications for metals in areas such as photonics, sensing, imaging, and medicine are also being developed. Significantly, most of these applications require the use of metals in the form of nanostructures with specific controlled properties.

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We report a case of primary non-Hodgkin gastric stump lymphoma, found in a 78-year-old man 30 years after a distal gastrectomy for a benign peptic ulcer. The development of lymphoma in the gastric stump is rare. In fact, to our knowledge only 37 cases, including this one, have been documented.

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