Publications by authors named "Antonazzo I"
Aims: This study aimed to assess the proportions of type 2 diabetes (T2D) subjects meeting cardiovascular outcome trials (CVOTs) criteria for sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and estimate SGLT2i utilization, along with associated demographic and clinical characteristics, in a primary care setting.
Methods: T2D patients in Italy were selected between January 1, 2021, and December 31, 2022, from The Health Improvement Network (THIN) database. Representativeness was determined by dividing patients meeting key inclusion criteria for four CVOTs (CANVAS, DECLARE-TIMI 58, EMPA-REG OUTCOME, VERTIS-CV) to the total T2D population.
Article Synopsis
- - Psoriatic arthritis (PsA) is linked to high direct and indirect costs, primarily from medications, hospital stays, and work absenteeism; this study updated previous analyses on the economic aspects of PsA.
- - Out of 27 studies, it was found that biologic therapies, particularly bimekizumab and ixekizumab, showed better cost-effectiveness compared to non-biologic treatments for managing PsA.
- - Despite an increase in economic evaluations since the last review, PsA remains a significant economic burden globally, indicating a need for further studies to understand its financial impact better.
Background: The adjuvanted recombinant zoster vaccine (RZV), consisting of varicella-zoster virus glycoprotein E (gE) and the AS01 adjuvant system, effectively prevents herpes zoster (HZ). In the absence of a well-defined correlate of protection, it is important to monitor the RZV immune response, as a proxy of clinical effectiveness.
Methods: This systematic review examined post-vaccination parameters: humoral and cell-mediated immunity, avidity index, geometric mean concentration of antibody (GMC), and immunity persistence.
Objectives: To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE.
Methods: A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017-2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics.
Aim: In 2022, in Italy, general practitioners (GPs) have been allowed to prescribe SGLT2i in Type 2 Diabetes (T2D) under National Health Service (NHS) reimbursement. In the pivotal clinical trial named DECLARE-TIMI 58, dapagliflozin reduced the risk of hospitalization for heart failure, CV death and kidney disease progression compared to placebo in a population of T2D patients. This study evaluated the health and economic impact of dapagliflozin for T2D patients who had or were at risk for atherosclerotic cardiovascular disease in the Italian GPs setting.
View Article and Find Full Text PDFAs respiratory syncytial virus (RSV) vaccine distribution gains traction in Europe and Italy, healthcare workers (HCWs) can strategize about vaccine promotion to increase uptake among patients at risk of RSV consequences, such cardiac patients. This cross-sectional survey investigated the knowledge about and attitude towards RSV and RSV vaccines, and the intention to recommend vaccination within a cardiological hospital in Italy. To explore factors associated with the outcomes of interest, multivariate logistic regression analyses were conducted.
View Article and Find Full Text PDF: Cardiac patients are particularly at risk of herpes zoster (HZ), which is associated with a higher risk of major cardiovascular events. This research aimed to analyze the knowledge, attitudes and practices towards recombinant zoster vaccine (RZV) among cardiac healthcare professionals (HPs). : A cross-sectional survey was conducted in a cardiological hospital in Italy.
View Article and Find Full Text PDFThis study aimed to assess the effectiveness and costs associated with pharmacokinetics-driven (PK) prophylaxis based on the myPKFiT device in patients affected by hemophilia A (HA) in Italy. An observational retrospective study was conducted in three Italian hemophilia centers. All patients with moderate or severe HA, aged ≥ 18 years, capable of having PK estimated using the myPKFiT device, and who had had a clinical visit between 1 November 2019 and 31 March 2022 were included.
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- - A study was conducted to gather updated insights on the psychosocial issues faced by adult people with hemophilia (PwH) and caregivers of children with hemophilia (CPwH) in Italy, as previous data was outdated and insufficient.
- - Surveys were administered to 120 adult PwH and 79 CPwH from November 2019 to June 2020, revealing significant impairments in work, family relationships, and social interactions among adult patients, while caregivers generally reported better psychosocial outcomes.
- - Key findings showed that both PwH and CPwH struggled with mobility, pain, and mental health, highlighting the need for increased genetic counseling and psychological support, since many were unaware of their carrier status and lacked
Article Synopsis
- Essential tremor (ET) is a common neurological disorder, and this study aimed to analyze its treatment patterns and characteristics in newly diagnosed patients in France and the UK from 2015 to 2018.
- Out of 2957 patients in the UK and 3249 in France, about 40% received treatment after diagnosis, but only 20% continued the treatment by the end of the follow-up, with many switching or stopping medications altogether.
- The findings indicate that ET is often undertreated, particularly among patients with psychiatric conditions, prompting a need for better identification and management of the disorder.
Introduction: Clinical trials confirmed the beneficial effects of adding pertuzumab (P) to the combination of trastuzumab-chemotherapy (TC) in the (neo)adjuvant setting of high-risk HER2-positive early breast cancer (HER2+BC). We evaluated the clinical, economic and societal impact of adding pertuzumab to neoadjuvant TC combination (TPC) in Italy.
Methods: A cost-consequence analysis comparing TPC vs.
We explored temporal variations in disease burden of ambient particulate matter 2.5 μm or less in diameter (PM) and ozone in Italy using estimates from the Global Burden of Disease Study 2019. We compared temporal changes and percent variations (95% Uncertainty Intervals [95% UI]) in rates of disability adjusted life years (DALYs), years of life lost, years lived with disability and mortality from 1990 to 2019, and variations in pollutant-attributable burden with those in the overall burden of each PM- and ozone-related disease.
View Article and Find Full Text PDFBackground: Recent developments improved outcomes in patients with autoimmune diseases. Biologics were approved as first-line treatment in selected naïve patients with plaque psoriasis (PsO), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Among them, secukinumab was most recently approved for treatment of active nr-axSpA in adults.
View Article and Find Full Text PDFBackground: This study was aimed at estimating the appropriate price of tucatinib plus trastuzumab and capecitabine (TXC), as third-line treatment, in HER2 breast cancer (BC) patients from the Italian National Health System (NHS) perspective.
Methods: A partitioned survival model with three mutually exclusive health states (i.e.
Background: The role of statins among patients with established cardiovascular diseases (CVDs) who are hospitalized with COVID-19 is still debated. This study aimed at assessing whether the prior use of statins was associated with a less severe COVID-19 prognosis.
Methods: Subjects with CVDs infected with SARS-CoV-2 and hospitalized between 20 February 2020 and 31 December 2020 were selected.
Article Synopsis
- - The study investigates the incidence of essential tremor (ET), a common movement disorder, in the UK and France from 2014 to 2019 using data from the Health Improvement Network database.
- - A total of around 5,000 new cases were identified in both countries, revealing an average crude incidence rate of approximately 18.20 in the UK and 21.42 in France, with higher rates typically seen in males and older age groups.
- - Despite similar standardized incidence rates in both countries, an increasing trend was noted, particularly among individuals aged 60 years and older, highlighting the necessity for further research on ET's impact on healthcare resources and disease management.
Objectives: Previous studies ruled out the benefits of azithromycin for treatment of patients with COVID-19 who are hospitalized. However, the effects of azithromycin for treatment of patients with positive SARS-CoV-2 test results in the community remains a matter of debate. This study aimed to assess whether azithromycin, when used in subjects with positive test results for SARS-CoV-2, is associated with a reduced risk of hospitalization, in-hospital COVID-19 outcomes, and death.
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- New rFVIII products like BAY 81-8973 show promise in personalizing treatments for hemophilia A, potentially cutting down on infusions and bleeding risks.
- A study conducted in five Italian centers compared the bleeding rates and FVIII consumption of 44 patients who switched from standard therapies to BAY 81-8973 over a year.
- Results indicated a significant drop in annual bleeding rates and FVIII usage, with more patients experiencing zero bleeds, suggesting that BAY 81-8973 could offer improved outcomes in real-world settings.
Article Synopsis
- Injury is a significant public health concern in Europe, with notable differences in injury death rates and disability-adjusted life years (DALYs) across sub-regions and countries, particularly between Eastern, Central, and Western Europe.
- The study analyzed GBD 2019 data from 44 European countries over 20 years, focusing on injury mortality and DALY rates by cause and sex while assessing inequalities based on country comparisons.
- Findings reveal that Eastern Europe has the highest injury death rates (80 deaths per 100,000), while Italy has the lowest injury DALY rate, indicating that males experience greater disparities in injury impact than females.
Background: Siponimod is an effective treatment for patients with secondary progressive multiple sclerosis (SPMS), with active disease evidenced by relapses or imaging features characteristic of multiple sclerosis inflammatory activity, however there is a need to evaluate its economic value and sustainability compared to other disease modifying-therapies (DMTs).
Objective: To estimate the siponimod cost-effectiveness profile and its relative budget impact compared with other DMTs, by using the Italian National Healthcare System perspective.
Methods: We performed: 1) a cost-effectiveness analysis (CEA) vs interferon beta-1b using an analytical Markov model and a life time-horizon, and 2) a budget impact analysis by using 3-years time-horizon.
In Italy, during the COVID-19 waves two lockdowns were implemented to prevent virus diffusion in the general population. Data on antidepressant (AD) use in these periods are still scarce. This study aimed at exploring the impact of COVID-19 lockdowns on prevalence and incidence of antidepressant drug use in the general population.
View Article and Find Full Text PDFIntroduction: Haemophilia management and patients' quality of life significantly improved. However, data on current patients', caregivers' and clinicians' satisfaction and limitations of treatments and haemophilia management are limited.
Aim: Assessing the management satisfaction and unmet needs from the perspective of Italian patients with haemophilia (PWH) without inhibitors (or caregivers if children) and of specialist physicians.
Background: The European post-authorisation study (EU PAS) register is a repository launched in 2010 by the European Medicines Agency (EMA). All EMA-requested PAS, commonly observational studies, must be recorded in this register. Multi-database studies (MDS) leveraging secondary data have become an important strategy to conduct PAS in recent years, as reflected by the type of studies registered in the EU PAS register.
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