Publications by authors named "Anton Saevskiy"

Article Synopsis
  • Sleep disruption in older adults is linked to chronic neuroinflammation in the preoptic and basal forebrain area, affecting sleep regulation.
  • Researchers introduced a viral vector to increase tumor necrosis factor-alpha (TNFα) in young mice, leading to heightened neuroinflammation and changes in sleep patterns.
  • Results showed that these mice experienced impaired sleep organization, decreased functionality of key sleep neurons, and reduced physical performance, indicating a connection between neuroinflammation and sleep disturbances as seen in aging.
View Article and Find Full Text PDF

The ventrolateral preoptic area (VLPO) contains GABAergic sleep-active neurons. However, the extent to which these neurons are involved in expressing spontaneous sleep and homeostatic sleep regulatory demands is not fully understood. We used calcium (Ca) imaging to characterize the activity dynamics of VLPO neurons, especially those expressing the vesicular GABA transporter (VGAT) across spontaneous sleep-waking and in response to homeostatic sleep demands.

View Article and Find Full Text PDF

The ventrolateral preoptic area (VLPO) predominantly contains sleep-active neurons and is involved in sleep regulation. The perifornical-hypothalamic area (PF-HA) is a wake-regulatory region and predominantly contains wake-active neurons. VLPO GABAergic/galaninergic neurons project to the PF-HA.

View Article and Find Full Text PDF

Neural oscillations of the mammalian olfactory system have been studied for decades. This research suggests they are linked to various processes involved in odor information analysis, depending on the vigilance state and presentation of stimuli. In addition, the effects of various anesthetics, including commonly used ones like chloral hydrate, pentobarbital, ketamine, and urethane, on the local field potential (LFP) in the olfactory bulb (OB) have been studied.

View Article and Find Full Text PDF