Publications by authors named "Anton O Vitovtov"
Article Synopsis
- Mitochondrial dysfunction plays a crucial role in brain aging and Alzheimer's disease (AD), and strategies targeting mitochondria are viewed as promising for prevention and treatment of AD.* -
- The study tested SkQ1, a mitochondria-targeted antioxidant, on OXYS rats that mimic AD symptoms, evaluating effects on behavior, neurodegeneration, and mitochondrial health over five months.* -
- SkQ1 treatment improved behavioral activity and reduced harmful amyloid-β protein levels in both rat types, while it helped maintain mitochondrial integrity by decreasing damaged mitochondria in OXYS rats, suggesting its potential as a therapeutic approach against AD.*
Article Synopsis
- Senescence-accelerated OXYS rats are a specialized model for accelerated aging research, developed through selective breeding from Wistar rats to exhibit cataract formation and rapid aging.
- These rats show early signs of behavioral and memory impairments starting at four weeks old, along with neurodegenerative changes observable through imaging techniques.
- Research indicates that OXYS rats develop Alzheimer's disease (AD)-like pathology, featuring overproduction of amyloid precursor proteins and tau protein abnormalities, making them a valuable model for studying AD mechanisms.
Cellular and organismal aging are driven in part by the MTOR (mechanistic target of rapamycin) pathway and rapamycin extends life span inC elegans, Drosophila and mice. Herein, we investigated effects of rapamycin on brain aging in OXYS rats. Previously we found, in OXYS rats, an early development of age-associated pathological phenotypes similar to several geriatric disorders in humans, including cerebral dysfunctions.
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