Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene.

Inhaled corticosteroids (ICS) are one of the most commonly used asthma therapies and have highly variable treatment success. Polymorphisms in TBX21, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics. We genotyped for rs9910408 in TBX21 in 208 adult asthmatic patients, treated at least 3 years with ICS.

Allergic bronchopulmonary aspergillosis with coexistant aspergilloma: a case report.

Introduction: The coexistence of allergic bronchopulmonary aspergillosis and aspergilloma is rare.

Case Presentation: We present the case of a 56-year-old Caucasian man who worked as a farmer, with infiltrates in the right lower and middle lung lobes, partial consolidation of the middle lobe and with previous diagnosis of chronic obstructive bronchitis. Evaluation of our patient led to the diagnosis of allergic bronchopulmonary aspergillosis with coexistent aspergilloma in the right lower lobe.