Publications by authors named "Anton Lahusen"

Background: Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. PDAC is described as a "cold" tumor type with poor infiltration by T cells and factors leading to intratumoral T cell suppression have thus received less attention. Here, we identify a cancer cell-intrinsic mechanism that contributes to a T cell-resistant phenotype and describes potential combinatorial therapy.

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Article Synopsis
  • * The INTERaction with Organoid-in-MatriX ("InterOMaX") model provides a 3D co-culture system that closely mimics the tumor microenvironment (TME), allowing researchers to explore how cancer cells and T cells interact.
  • * This model facilitates the discovery of new molecular mechanisms affecting T cell responses to PDAC, which could lead to improved understanding of why some cancer cells resist treatment and ultimately enhance therapeutic strategies.
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