Methylene C(sp )-H Arylation Enables the Stereoselective Synthesis and Structure Revision of Indidene Natural Products.

The divergent synthesis of two indane polyketides of the indidene family, namely (±)-indidene A (11 steps, 1.7 %) and (+)-indidene C (13 steps, 1.3 %), is reported.

Site-Selective Pd-Catalyzed C(sp )-H Arylation of Heteroaromatic Ketones.

A ligand-controlled site-selective C(sp )-H arylation of heteroaromatic ketones has been developed using Pd catalysis. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- to β-arylation was realized by addition of a pyridone ligand.

Chiral Catalysts for Pd -Catalyzed Enantioselective C-H Activation.

In the past few decades, processes that involve transition-metal catalysis have represented a major part of the synthetic chemist's toolbox. Recently, the interest has shifted from the well-established cross-coupling reactions to C-H bond functionalization, thus making it a current frontier of transition-metal-catalyzed reactions. Constant progress in this field has led to the discovery of enantioselective methods to generate and control various types of stereogenic elements, thereby demonstrating its high value to generate scalemic chiral molecules.