Low cytotoxicity and clastogenicity of some polymeric aminophosphonate derivatives.

Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were tested for antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells and for clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, both and and lower clastogenicity than the corresponding low-molecular aminophosphonates. The biological activities of the tested polymers correlate with their low antitumor activity.

Chemical structure and in vitro antitumor activity of rhamnolipids from Pseudomonas aeruginosa BN10.

A newly isolated indigenous strain BN10 identified as Pseudomonas aeruginosa was found to produce glycolipid (i.e., rhamnolipid-type) biosurfactants.

In vitro antitumour activity, genotoxicity, and antiproliferative effects of aminophosphonic acid diesters and their synthetic precursors.

The Schiff bases N-furfurylidene-p-toluidine and N-(4-dimethylaminobenzilidene)-p-toluidine, and the recently synthesized aminophosphonic acid diesters p-[N-methyl-(diethoxyphosphonyl)-(2-furyl)]toluidine and p-[N-methyl(diethoxyphosphonyl)-(4-dimethylaminophenyl)]toluidine were tested for in vitro antitumour activity on six human epithelial cancer cell lines. The genotoxicity and antiproliferative activity of these compounds were tested in mice. The aminophosphonates showed high in vitro antitumour activity towards the breast cancer-derived cell lines (MCF-7 and MDA-MB-231), the cervical carcinoma cell line (HeLa), and the human colon adenocarcinoma cell line (HT-29).

Investigation of the morphology of cell clones, derived from the mammalian EBTr cell line and their susceptibility to vaccine avian poxvirus strains FK and Dessau.

The ability for replication of vaccine avian pox viral strains FK and Dessau in cell clones, derived from the EBTr cell line, derived from embryonic bovine trachea, was studied. The derived seven cell clones showed different morphological characteristics and diverse sensitivity to both vaccine avian pox viral strains. Hence, the EBTr-derived cell clones could be used for cultivation, as well as for differentiation of vaccine avian pox viral strains.