Plastic Surgery Pioneers of the Central Powers in the Great War.

Plastic surgical techniques were described in antiquity and the Middle Ages; however, the genesis of modern plastic surgery is in the early 20th century. The exigencies of trench warfare, combined with medical and technological advances at that time, enabled pioneers such as Sir Harold Gillies to establish what is now recognized as plastic and reconstructive surgery. The physicians of Germany, Russia, and the Ottoman Empire were faced with the same challenges; it is fascinating to consider parallel developments in these countries.

Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study.

Background: Currently, patients receiving vascularized composite allotransplantation (VCA) grafts must take long-term systemic immunosuppressive therapy to prevent immunologic rejection. The morbidity and mortality associated with these medications is the single greatest barrier to more patients being able to receive these life-enhancing transplants. In contrast to solid organs, VCA, exemplified by hand or face transplants, allow visual diagnosis of clinical acute rejection (AR), directed biopsy and targeted graft therapies.

Patient-Reported Outcome Measures for Toe-to-Hand Transfer: A Prospective Longitudinal Study.

Background: Patient-reported outcome measures are an important metric in evaluating treatment efficacy of reconstructive surgery. Toe-to-hand transfer can restore vital prehensile function; however, this surgery is complex, extensive rehabilitation is required, and there are concerns about donor-site morbidity. This study longitudinally explores the benefits of this procedure, from the patient's perspective, using patient-reported outcome measures.

Composite Graft Pretreatment With Hydrogen Sulfide Delays the Onset of Acute Rejection.

Introduction: Vascularized composite allotransplantation can reconstruct devastating tissue loss by replacing like-with-like tissues, most commonly in the form of hand or face transplantation. Unresolved technical and ethical challenges have meant that such transplants remain experimental treatments. The most significant barrier to expansion of this field is the requirement for systemic immunosuppression, its toxicity and effect on longevity.

A Porcine Orthotopic Forelimb Vascularized Composite Allotransplantation Model: Technical Considerations and Translational Implications.

Background: The restoration of complex tissue deficits with vascularized composite allotransplantation is a paradigm shift in reconstructive surgery. Clinical adoption of vascularized composite allotransplantation is limited by the need for systemic immunosuppression, with associated morbidity and mortality. Small-animal models lack the biological fidelity and preclinical relevance to enable translation of immunologic insights to humans.

C1 esterase inhibitor ameliorates ischemia reperfusion injury in a swine musculocutaneous flap model.

Purpose: Free tissue transfer is a powerful reconstructive surgical technique. The ischemia reperfusion injury (IRI) at revascularization affects the flap and the patient; reducing this insult could improve outcomes. This study evaluated the effect of C1 esterase inhibitor (C1-inh) on IRI in a porcine musculocutaneous flap model.

High velocity gunshot injuries to the extremities: management on and off the battlefield.

The gunshot wounds sustained on the battlefield caused by military ammunition can be different in nature to those usually encountered in the civilian setting. The main difference is that military ammunition has typically higher velocity with therefore greater kinetic energy and consequently potential to destroy tissue. The surgical priorities in the management of gunshot wounds are hemorrhage control, preventing infection, and reconstruction.

Hydrogen sulfide mitigates reperfusion injury in a porcine model of vascularized composite autotransplantation.

Background: Devastating extremity injuries are prevalent but often survivable on the modern battlefield. These complex injuries require advanced methods of reconstruction, involving prolonged ischemic periods and reperfusion injury. Using our group's validated porcine model of gracilis myocutaneous flap transplantation, this study demonstrates that an interim perfusion of hydrogen sulfide (H2S) mitigates the effects of reperfusion injury in the setting of delayed restoration of blood flow.

Military trauma care in Birmingham: observational study of care requirements and resource utilisation.

Background: The Royal Centre for Defence Medicine is located at University Hospitals Birmingham (UHB). Since 2001 all UK military casualties injured on active duty have been repatriated here for their initial treatment. This service evaluation was performed to quantify the work undertaken, with the aim of providing a snapshot of a year's military trauma work in order to inform the delivery of trauma care in both the military and civilian setting.

Use of topical negative pressure in british servicemen with combat wounds.

Objective: The objective of this study was to characterize the use of topical negative pressure therapy in combat wounds.

Methods: This study was a retrospective review of the records of patients whose wounds were managed with topical negative pressure between April 2007 and March 2008. The main outcome measure was episodes of antibiotic prescription, which was used as a surrogate marker of clinically relevant infection.