Publications by authors named "Antoine Roland"
Molecular catch bonds are ubiquitous in biology and essential for processes like leucocyte extravasion and cellular mechanosensing. Unlike normal (slip) bonds, catch bonds strengthen under tension. The current paradigm is that this feature provides 'strength on demand', thus enabling cells to increase rigidity under stress.
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- The study highlights the role of polypeptide collapse in protein folding, aggregation, and disorder, emphasizing its importance in cellular processes.
- Researchers found that the chaperonin GroEL-ES enhances protein folding by inducing contractile forces that help proteins compact and transition into their folded states.
- This collapse enhancement mechanism, particularly effective when GroEL is bound to nucleotides, is distinct from other known methods of folding acceleration and suggests that collapse modulation may play a crucial role in protein quality control in cells.
Background: F-fluorocholine positron emission tomography/computed tomography (F-choline PET/CT) is considered a cornerstone in the staging and restaging of patients with prostate cancer (PCa). The aim of this study was to retrospectively assess unusual uptakes in patients who underwent a F-choline PET/CT for the initial staging or for the restaging of a relapsing PCa.
Methods: Three hundred and sixty-eight PCa patients were staged or restaged using F-choline PET/CT.
Background: Enterocolitis is a rare, but serious gastrointestinal complication associated with docetaxel-based chemotherapy in patients with cancer. The incidence, clinical presentation and outcome of enterocolitis in patients with cancer treated with docetaxel-based chemotherapy was assessed in this study Patients and Methods: All patients treated with docetaxel for cancer between January 2010 and December 2014 at the University Hospital of Besançon were identified and their medical records reviewed.
Results: During this period, 1,227 patients received docetaxel chemotherapy and gastrointestinal events occurred in 381 (31.