Publications by authors named "Antoine Paris"
Article Synopsis
- * Researchers developed a strategy targeting bacterial nucleotide excision repair (NER) and screened ~120,000 compounds to identify potential antimicrobial sensitizers, leading to the discovery of Bemcentinib (R428) as a promising candidate.
- * Bemcentinib inhibits the NER protein UvrA's ATPase activity and DNA binding, effectively reducing its DNA repair capabilities, and shows significant growth inhibition of E. coli when combined with DNA-damaging agents like cisplatin, suggesting its potential as an adjuvant in cancer therapy.
Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune system. The resulting neutropenia predisposes patients to infection, which delays treatment and is a major cause of morbidity and mortality. To tackle this problem, we have isolated several compounds that inhibit bacterial DNA repair, alone they are non-toxic, however in combination with DNA damaging anti-cancer drugs, they prevent bacterial growth.
View Article and Find Full Text PDFIn bacteria, nucleotide excision repair (NER) plays a major role in repairing DNA damage from a wide variety of sources. Therefore, its inhibition offers potential to develop a new antibacterial in combination with adjuvants, such as UV light. To date, only one known chemical inhibitor of NER is 2-(5-amino-1,3,4-thiadiazol-2-yl)benzo(f)chromen-3-one (ATBC) exists and targets Mycobacterium tuberculosis NER.
View Article and Find Full Text PDFObjectives: To present the surgical results and the functional outcomes after surgical correction of congenital penile curvature (CPC) by different plication techniques.
Methods: All consecutive patients operated for CPC from 2010 to 2019 in a university hospital of Lyon, France, were retrospectively identified and included for analyzing surgical results. They were proposed to answer a questionnaire (between January 2020 and May 2020) that included questions of the Peyronie's Disease Questionnaire (PDQ), the Erection Hardness Score (EHS), and the Internal Index of Erectile Function (IIEF5), along with non-validated specific questionnaires.