Safety and efficacy of apixaban versus warfarin in peritoneal dialysis patients with non-valvular atrial fibrillation: protocol for a prospective, randomised, open-label, blinded endpoint trial (APIDP2).

Introduction: Several randomised controlled trials have demonstrated that novel oral anticoagulants are safer compared with vitamin K antagonists for the management of non-valvular atrial fibrillation (NVAF) to prevent thromboembolic events in the general population. There is a growing interest in the use of apixaban in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD) but there is a lack of randomised data in this population.

Methods And Analysis: APIDP2 is a prospective parallel, randomised, open-label, blinded endpoint trial involving patients with ESRD undergoing chronic PD who have NVAF.

Separation efficiency of a hydrodynamic separator using a 3D computational fluid dynamics multiscale approach.

The aim of this study is to investigate the use of computational fluid dynamics (CFD) to predict the solid separation efficiency of a hydrodynamic separator. The numerical difficulty concerns the discretization of the geometry to simulate both the global behavior and the local phenomena that occur near the screen. In this context, a CFD multiscale approach was used: a global model (at the scale of the device) is used to observe the hydrodynamic behavior within the device; a local model (portion of the screen) is used to determine the local phenomena that occur near the screen.

Optimization of a hydrodynamic separator using a multiscale computational fluid dynamics approach.

This article deals with the optimization of a hydrodynamic separator working on the tangential separation mechanism along a screen. The aim of this study is to optimize the shape of the device to avoid clogging. A multiscale approach is used.

Aperture effect correction in spectroscopic full-field optical coherence tomography.

Spatially resolved spectroscopic optical coherence tomography (OCT) has been demonstrated to be a convenient tool for spectral analysis in turbid media. For a full-field OCT configuration using a Mirau objective in the visible range, we found that the effective numerical aperture varies over the field of view, leading to field-dependent spectral shifts in the reconstructed spectra. Interferograms recorded with quasi-monochromatic lights are theoretically fitted with a general Mirau interference formula, and we propose a numerical correction method for white-light spectroscopy.

Ectopic gene conversions increase the G + C content of duplicated yeast and Arabidopsis genes.

Allelic recombination has previously been shown to increase the GC-content of the sequences of a wide variety of eukaryotic species. Ectopic recombination between clustered tandemly repeated genes has also been shown to increase their GC-content. Here we show that gene conversions between the dispersed genes found in the duplicated regions of the yeast and Arabidopsis genomes also increase their GC-content when these genes are more than 88% similar.