Publications by authors named "Antoine Modia O'yandjo"
Comparative effectiveness of sildenafil citrate and estradiol valerate as adjuvants during clomiphene citrate-assisted ovarian stimulation cycles in patients with unexplained infertility: a double-blind randomized controlled trial.
Contracept Reprod Med
October 2024
Article Synopsis
- The study aimed to evaluate the effectiveness of sildenafil citrate and estradiol valerate as additional treatments during ovarian stimulation cycles in women with unexplained infertility.
- Conducted over two years, the double-blind trial involved 148 patients split into two groups, one receiving sildenafil with clomiphene citrate and the other receiving estradiol valerate with clomiphene citrate, focusing on conception rates and related outcomes.
- Results showed that the group taking sildenafil had a significantly higher clinical pregnancy rate and better ovulation rates compared to the estradiol group, suggesting sildenafil is a more effective adjuvant therapy for this condition.
Comparison of Adding Sildenafil Versus Estradiol to Clomiphene Citrate on the Applebaum Score and Pregnancy Rate in Patients With Unexplained Infertility: A Double-Blind Randomized Controlled Trial.
Cureus
June 2024
Background: Both sildenafil and estradiol are seen to improve endometrial thickness in patients with infertility who are undergoing clomiphene induction cycles. However, the correlation between endometrial thickness and pregnancy rate is debatable. This study investigated the effect of adding oral sildenafil to clomiphene citrate (CC), compared to adding estradiol valerate, on the uterine biophysical profile (Applebaum score) and pregnancy rate.
View Article and Find Full Text PDFBackground: In sub-Saharan Africa, tubal factors are described as the main aetiological factors of infertility. Under these conditions, medically assisted procreation is particularly indicated. However, Assisted Reproductive Technology centres are less available.
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