Preventing Child Behavior Problems and Substance Use: The Pathways Home Foster Care Reunification Intervention.

This paper evaluated the Pathways Home manualized selective preventive intervention designed to prevent reunification failures once children are returned home to their biological parent(s) after first time stays in foster care ( = 101). The theoretically based intervention focused on support and parent management practices designed to prevent the development of child behavior problems including internalizing and externalizing problems, and substance use. Intent to treat analyses employed probability growth curve approaches for repeated telephone assessments over 16 weeks of intervention.

Cameroonemide A: a new ceramide from Helichrysum cameroonense.

From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data.

A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo.

The OZF (ZNF146) protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. It is overexpressed in the majority of pancreatic cancers and in more than 80% of colorectal cancers. We have identified OZF interacting factors with a yeast two-hybrid screen.

Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.

The OZF (ZNF146) protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. It is overexpressed in the majority of pancreatic cancers and in more than 80% of colorectal cancers. We found an interaction between OZF and the telomeric hRap1 protein with a yeast two-hybrid screen.

Use of radio-frequency ablation for the palliative treatment of sacral chordoma.

Chordomas are the most common sacrococcygeal tumors in adults. They have a high recurrence rate, are locally aggressive, and are resistant to radiation therapy. Radio frequency is a relatively new therapeutic technique, used primarily in the treatment of liver tumors; however, its application has widened to include other neoplasms.

Production and characterization of mouse monoclonal antibodies to human zinc finger OZF protein overexpressed in pancreatic carcinomas.

Mouse monoclonal antibodies (MAbs) were raised against the human OZF protein, a zinc finger protein of the Krüppel family, consisting of 10 amino acids followed by 10 zinc finger motives. The OZF gene is amplified in 15-25% of pancreatic carcinomas and protein overexpression occurs in more than half of the tumors. Six MAbs effective in detecting the recombinant and the cellular protein by enzyme-linked immunoadsorbent assay (ELISA), Western immunoblotting, and immunofluorescence were purified and characterized.

[Is there a correlation between dietary habits and hemorrhoidal disease?].

Objectives: It is empirically accepted that certain foods play a role in the pathogenesis of hemorrhoids or their acute exacerbation. The aim of this work was to determine whether there is a relationship between hemorrhoids and certain food-related or common toxin-related factors.

Patients And Methods: Two groups of 50 subjects were compared.

Simultaneous bilateral oophorectomy does not improve prognosis of postmenopausal women undergoing colorectal resection for cancer.

Purpose: Synchronous or metachronous ovarian metastases are common along the natural course of colorectal carcinoma. We attempted to prospectively assess the prognostic impact of simultaneous bilateral oophorectomy in postmenopausal women undergoing curative resection for colorectal cancer.

Methods: Between 1980 and 1990, simultaneous bilateral oophorectomy was proposed in each postmenopausal woman referred to our institution for treatment of colorectal cancer.