Publications by authors named "Antoine Gagelin"
Article Synopsis
- Brown adipose tissue utilizes uncoupling protein 1 (UCP1) to produce heat, making it a potential target for metabolic disorder treatments.
- Research reveals that purine nucleotides like GDP and GTP inhibit UCP1's respiration uncoupling by binding at a specific site, with key interactions involving certain amino acids.
- Mutations in specific residues (I187A and W281A) enhance UCP1 activity, highlighting how these changes can lead to increased uncoupling even in the presence of purine nucleotides.
