Publications by authors named "Antoine Desmet"
Postoperative radiotherapy (RT) has been shown to effectively reduce disease recurrence and mortality in breast cancer (BC) treatment. A critical step in the planning workflow is the accurate delineation of clinical target volumes (CTV) and organs-at-risk (OAR). This literature review evaluates recent advancements in deep-learning (DL) and atlas-based auto-contouring techniques for CTVs and OARs in BC planning-CT images for RT.
View Article and Find Full Text PDFArticle Synopsis
- Luminal B breast cancer has a poorer prognosis and lower sensitivity to chemotherapy compared to Luminal A, leading to a clinical trial (Neo-CheckRay) that explores combining stereotactic body radiation therapy (SBRT) with the drug oleclumab to enhance treatment effectiveness.
- The safety run-in of the trial involved six patients receiving a neo-adjuvant treatment regimen, including chemotherapy and immunotherapy, followed by SBRT directed at the primary tumor before surgery.
- Results showed that the treatment was generally well-tolerated with only one minor adverse event reported, and all patients successfully completed their treatments with surgery occurring 2-4 weeks afterward.
Background: Intraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter overall treatment times and reduced irradiation of organs at risk. We report on our first 996 patients enrolled prospectively in a registry trial.
Methods: At Jules Bordet Institute, from February 2010 onwards, patients underwent partial IOERT of the breast.
Purpose/objective: Deep Inspiration Breath Hold (DIBH) is now considered as the standard of care for many breast cancer patients. However, there are still uncertainties about the dose given to the heart, and it is unknown if patients may improve voluntary DIBH depth by gaining experience during treatment. In this study, we will examine the interfractional three-dimensional (3D) heart displacement throughout voluntary DIBH (vDIBH) radiotherapy by means of daily cone-beam computed tomography (CBCT).
View Article and Find Full Text PDFDue to the general aging population and the fashion trend of sun exposure, non-melanoma skin cancer (NMSC) is rising. The management of NMSC is difficult and necessitates a multidisciplinary team (i.e.
View Article and Find Full Text PDFBackground And Purpose: To evaluate dosimetric differences in unintended dose to the lower axilla between 3D-standard (3DCRT), tangential beam forward intensity modulated radiotherapy (F-IMRT) and volumetric modulated arc therapy (VMAT). The objective is to evaluate whether results of clinical trials, such as the ACOSOG-Z011 trial, that evaluated omission of axillary clearance can be extrapolated towards more conformal techniques like VMAT.
Materials And Methods: Twenty-five consecutive patients treated with whole breast radiotherapy alone (WBRT) using a F-IMRT technique were identified.