Publications by authors named "Antoine Carton-Leclercq"
The neocortex is highly susceptible to metabolic dysfunction. When exposed to global ischemia or anoxia, it suffers a slowly propagating wave of collective neuronal depolarization that ultimately impairs its structure and function. While the molecular signature of anoxic depolarization (AD) is well documented, little is known about the brain states that precede and follow AD onset.
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- A new rat model was created to study how neurons in the thalamo-cortical pathway respond during an isoelectric coma induced by isoflurane, which halts spontaneous brain activity.
- The electrocorticogram (ECoG) showed that there was complete cessation of synaptic activity, but individual neurons still exhibited some degree of excitability and sensory responses at a diminished level.
- These results suggest that even in a state of isoelectric brain activity, neurons may retain some capacity to respond to external stimuli, indicating a need to rethink the implications of drug-induced isoelectric states.
Article Synopsis
- Researchers created a new rodent model to study reversible brain anoxia, monitoring neuron activity and brain signals during the transition from dying to recovery.* -
- They observed a pattern where the brain's electrical activity changed, initially showing bursts of high-frequency signals, followed by low-frequency signals leading to a critical "wave-of-death" (WoD) that indicated severe neuron damage.* -
- Importantly, if oxygen was restored quickly, neurons could recover, producing a "wave-of-resuscitation," suggesting the WoD isn't a permanent sign of death and revealing potential biomarkers that could guide resuscitation efforts.*