Publications by authors named "Antoaneta Comarniceanu"
Article Synopsis
- The study evaluated the effectiveness of integrated Raman polarized light microscopy (iRPolM) in diagnosing calcium pyrophosphate (CPP)-associated arthritis using 400 samples from a hospital in the Netherlands.
- Results showed strong agreement between iRPolM and the 2023 ACR/EULAR criteria, with high sensitivity (86.0%) and specificity (99.1%).
- The findings suggest that iRPolM offers a reliable diagnosis for CPP crystals and could improve outcomes for patients compared to traditional polarized light microscopy.
Objectives: We studied the performance of Raman spectroscopy integrated with polarized light microscopy (iRPolM) as a next-generation technique for synovial fluid analysis in gout.
Methods: This is a prospective study, including consecutive synovial fluid samples drawn from any peripheral swollen joint. Diagnostic accuracy was compared to the 2015 ACR/EULAR Gout classification criteria as a reference test and to polarized light microscopy (PLM) analysis by a rheumatologist.
Background: Gout flares are driven by interleukin (IL)-1β. Dapansutrile inhibits the NLRP3 inflammasome and subsequent activation of IL-1β. In this study we aimed to investigate the safety and efficacy of orally administered dapansutrile in patients with a gout flare.
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