Arch Otolaryngol Head Neck Surg
June 2008
Objective: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function.
Design: Prospective, before-after trial.
Setting: Outpatient clinic of a university clinic for otorhinolaryngology.
The olfactory bulb is a highly plastic structure the volume of which partly reflects the degree of afferent neural activity. In this study, 22 patients with post-infectious olfactory deficit, nine participants with post-traumatic olfactory deficit, and 17 healthy controls underwent magnetic resonance volumetry of the olfactory bulb. Patients presented with significantly smaller olfactory bulb volumes than controls; significant correlations between olfactory function and bulb volume were observed.
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