Publications by authors named "Antje J Neeb"
Article Synopsis
- Endocrine resistance in advanced prostate cancer is driven by proteins like AR-V7, with JMJD6 being a key regulator of its production.
- The study found that increasing levels of JMJD6 correlate with higher AR-V7 levels and reduced survival rates in patients.
- JMJD6 knockdown led to reduced prostate cancer cell growth and less AR-V7, suggesting that targeting JMJD6 could be a promising therapy for combating prostate cancer.
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators that regulate AR activity, including the paralog histone acetyltransferase proteins p300 and CBP, are attractive therapeutic targets for lethal prostate cancer. Herein, we validate targeting p300/CBP as a therapeutic strategy for lethal prostate cancer and describe CCS1477, a novel small-molecule inhibitor of the p300/CBP conserved bromodomain.
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