Publications by authors named "Antiopi Vardaxi"

This study demonstrates the valorization of sugar beet pulp (SBP)-derived pectin to produce bio-based coatings for shrimp preservation. Pectin extraction was assessed at varying temperatures and extraction times to achieve tailored properties (high methoxyl-pectins, degree of esterification-DE >79.0 %) leading to 11.

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The present study concerns the preparation of hybrid nanostructures composed of carbon dots (CDs) synthesized in our lab and a double-hydrophilic poly(2-dimethylaminoethyl methacrylate--oligo(ethylene glycol) methyl ether methacrylate) (P(DMAEMA--OEGMA)) random polymer through electrostatic interactions between the negatively charged CDs and the positively charged DMAEMA segments of the polymer. The synthesis of P(DMAEMA--OEGMA) polymer was conducted through RAFT polymerization. Furthermore, the polymer was converted into a strong cationic random polyelectrolyte through quaternization of the amine groups of DMAEMA segments with methyl iodide (CHI), and it was subsequently utilized for the complexation with the carbon dots.

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In this work, the synthesis and the stimuli-responsive self-assembly behavior of novel double-hydrophilic poly(2-(dimethylamino)ethyl methacrylate-co-(oligo ethylene glycol)methacrylate) random copolymers and their chemically modified derivatives are presented. The synthesis of P(DMAEMA-co-OEGMA) copolymers of different DMAEMA mass compositions was successfully conducted through RAFT polymerization, further followed by the hydrophilic/hydrophobic quaternization with methyl iodide (CHI), 1-iodohexane (CHI), and 1-iodododecane (CHI). The tertiary and quaternary amines are randomly arranged within the DMAEMA segment, responding thus to pH, temperature, and salt alterations in aqueous solutions.

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Over the last three decades, proteins and peptides have attracted great interest as drugs of choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and infectious and neurological diseases. However, the delivery of therapeutic proteins to target sites should take into account the obstacles and limitations related to their intrinsic sensitivity to different environmental conditions, fragile tertiary structures, and short half-life. Polymeric nanostructures have emerged as competent vehicles for protein delivery, as they are multifunctional and can be tailored according to their peculiarities.

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Synopsis of recent research by authors named "Antiopi Vardaxi"

  • - Antiopi Vardaxi's research focuses on the development and application of bio-based materials and polymeric nanostructures for various practical uses, including food preservation and drug delivery.
  • - Significant findings include the effective extraction of pectin from sugar beet pulp for shrimp preservation and the synthesis of hybrid nanoparticles for biomedical applications through electrostatic interactions in complex polymer systems.
  • - Vardaxi's studies demonstrate considerable advancements in stimuli-responsive self-assembly behaviors of copolymers, and the potential of polymeric nanostructures to enhance the delivery of sensitive therapeutic proteins, addressing key challenges in pharmaceutical applications.

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