Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.

Aim: Assuming that genetic variants of the SLC22A2 and SLC31A1 transporter affect patients' susceptibility to cisplatin-induced ototoxicity, we compared the distribution of 11 SLC22A2 variants and the SLC31A1 variant rs10981694 between patients with and without cisplatin-induced ototoxicity.

Patients & Methods: Genotyping was performed in 64 pediatric patients and significant findings were re-evaluated in 66 adults.

Results: The SLC22A2 polymorphism rs316019 (c.