Publications by authors named "Anthony Wei-Shine Chi"
Article Synopsis
- Group 2 innate lymphoid cells (ILC2) play a key role in defending against helminth infections and are also connected to allergic reactions in the airways.
- The development of ILC2 cells requires the transcription factor T cell factor 1 (TCF-1), which is also important for T cell development.
- Research shows that without TCF-1, mice cannot produce ILC2 and thus fail to initiate type 2 immune responses, indicating that similar transcriptional mechanisms are involved in both T cell and ILC2 development.
The vertebrate thymus provides an inductive environment for T-cell development. Within the mouse thymus, Notch signals are indispensable for imposing the T-cell fate on multipotential haematopoietic progenitors, but the downstream effectors that impart T-lineage specification and commitment are not well understood. Here we show that a transcription factor, T-cell factor 1 (TCF-1; also known as transcription factor 7, T-cell specific, TCF7), is a critical regulator in T-cell specification.
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