Publications by authors named "Anthony Verbeck"
Article Synopsis
- Neuronal dysfunction is a key aspect of neurodegenerative tauopathies, but immune cells like microglia also play a significant role in the disease's progression.
- This study shows that tau mRNA and protein are present in microglia and that a specific tau mutation (IVS10+16) can change how these immune cells behave, causing issues like cytoskeletal problems and stalled phagocytosis.
- Secretions from microglia with this mutation negatively affect neuron health, leading to decreased synaptic density, and similar characteristics were observed in human brain samples from mutation carriers, suggesting important implications for future therapies.
Astrocyte-specific ion pump α2-Na+/K+-ATPase plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we test the effect of Atp1a2 mRNA-specific antisense oligonucleotides (ASOs) to induce α2-Na+/K+-ATPase knockdown in the widely used ALS animal model, SOD1*G93A mice. Two ASOs led to efficient Atp1a2 knockdown and significantly reduced SOD1 aggregation in vivo.
View Article and Find Full Text PDFImpaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue. In a subset of frontotemporal lobar degeneration with tau pathology (FTLD-tau) cases, pathogenic mutations in the microtubule-associated protein tau (MAPT) gene are sufficient to cause tau accumulation and neurodegeneration.
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