Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates.

Background: Mass spectrometry is selective and sensitive, permitting routine quantification of multiple plasma proteins. However, commonly used nanoflow liquid chromatography (LC) approaches hamper sample throughput, reproducibility, and robustness. For this reason, most publications using plasma proteomics to date are small in study size.

Aberrant first fixations when looking at inverted faces in various poses: the result of the centre-of-gravity effect?

Face recognition is essential in everyday human life, and all faces are encountered in different poses. However, when a face is inverted, difficulties arise for recognition and eye movements may (Barton, Radcliffe, Cherkasova, Edleman, & Intriligator, 2006) or may not be disrupted (Williams & Henderson, 2007). The present study explored the effects of orientation and pose on recognition and eye movements during a standard old/new recognition task in order to resolve whether inversion disrupts eye movements.

Latency and accuracy of saccades to somatosensory targets.

Purpose: To examine the accuracy and latency of reflexive saccades to vibratory stimulation of the fingertips made by normal human subjects and to compare the findings to those of visually guided saccades.

Methods: Eye movements were recorded using infrared oculography. Stimuli were presented via an array of audiometric bone vibrator transducers driven at 250 Hz and positioned at eye level in a darkened room.

High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast.

Large-scale proteomics will play a critical role in the rapid display, identification and validation of new protein targets, and elucidation of the underlying molecular events that are associated with disease development, progression and severity. However, because the proteome of most organisms are significantly more complex than the genome, the comprehensive analysis of protein expression changes will require an analytical effort beyond the capacity of standard laboratory equipment. We describe the first high-throughput proteomic analysis of human breast infiltrating ductal carcinoma (IDCA) using OCT (optimal cutting temperature) embedded biopsies, two-dimensional difference gel electrophoresis (2-D DIGE) technology and a fully automated spot handling workstation.

Management of idiopathic pulmonary haemosiderosis in pregnancy: report of two cases.

Idiopathic pulmonary haemosiderosis (IPH) is a rare cause of alveolar haemorrhage. Its management in pregnancy is complicated and little clinical data exist on outcomes or treatment. Two patients with IPH, one with a known diagnosis prior to pregnancy (patient A) and one presenting de novo during pregnancy (patient B) are reported.

Gender differences in coping strategies of parents of children with Down syndrome.

Little research has been conducted on the reactions of parents, and fathers in particular, following the birth of a child with Down syndrome. Previous studies suggest that gender differences exist in coping strategies and a number of theories have supported this. The current study is informed by Pleck's (1981) Gender Role Strain model which attempts to explain the different socialisation processes males encounter which influence their development in our society.