Effects of nitazoxanide on pharmacokinetics and pharmacodynamics of a single dose of warfarin.

Purpose: The effects of nitazoxanide on warfarin pharmacokinetics and pharmacodynamics are examined.

Methods: This was a Phase I, single-center, open-label, randomized, two-way, crossover study. Secondary endpoints included an evaluation of the effect of nitazoxanide on coagulation parameters observed after a single dose of warfarin and an assessment of the overall tolerability of study treatments.