The Therapeutic Potential of Psychedelics on Reducing Rumination: A Mini-Review.

Rumination is a well-established risk factor for the onset and maintenance of depression and anxiety and is associated with various other forms of psychopathology (e.g., eating pathology, obsessive-compulsive disorder, posttraumatic stress disorder).

Toward Development of a Novel Proprioceptive Trail-Making Test: Comparing Healthy Dancers and Non-Dancers.

There is a pressing need for ecologically valid versions of traditional neuropsychological tests indexing executive function (EF), such as the Trail-Making Task (TMT), that incorporate movement and bodily awareness in healthy participants with varying abilities. We designed a proprioceptive version of the TMT (pTMT) that involved coordinated gross motor movement and proprioceptive awareness to investigate whether this measure of visual attention, task switching, and working memory positively correlated with a computerized version of the TMT (the dTMT). We aimed to establish the initial validity of our proprioceptive TMT (pTMT) by comparing performances on the dTMT and pTMT among a cohort of 36 healthy participants (18 dancers, 18 non-dancers; age = 22, = 5.

Increased pupil dilation during tip-of-the-tongue states.

Tip-of-the-tongue states (TOTs) are feelings of impending word retrieval success during a current failure to retrieve a target word. Though much is known and understood about TOT states from decades of research, research on potential psychophysiological correlates of the TOT state is still in its infancy, and existing studies point toward the involvement of neural processes that are associated with enhanced attention, motivation, and information-seeking. In the present study, we demonstrate that, during instances of target retrieval failure, TOT states are associated with greater pupillary dilation (i.

Trauma, posttraumatic stress disorder severity, and positive memories.

Positive memories play an important role in the aetiology and maintenance of posttraumatic stress disorder (PTSD). However, most trauma research/clinical work has focused solely on the role of traumatic memories. Thus, we examined the relationship between count of retrieved positive memories and PTSD severity, factors associated with count of retrieved positive memories (i.

Hemisphere-specific effects of prefrontal theta-burst stimulation on visual recognition memory accuracy and awareness.

Background: The prefrontal cortex has been implicated in episodic memory and the awareness of memory. Few studies have probed the nature and necessity of its role via brain stimulation. There are uncertainties regarding whether the hemisphere of stimulation predicts effects on memory and whether effects of stimulation are format-specific, with most previous studies utilizing verbal/semantic stimuli.

Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.

Nearly three out of four survivors experience Cancer-Related Cognitive Impairment (CRCI) for months or years following treatment. Both clinical and animal studies point to the hippocampus as a likely brain region affected in CRCI, however no previous study has investigated the functional connectivity of the hippocampus in CRCI. We compared hippocampal connectivity in cancer survivors and healthy controls and tested the relationship between functional connectivity differences and measures of objective and subjective cognition.

Memory awareness disruptions in amnestic mild cognitive impairment: comparison of multiple awareness types for verbal and visuospatial material.

Successful memory is normally accompanied by explicit awareness of retrieval and confidence in the accuracy of the retrieval product. Prior findings suggest that these features of metamemory can be dissociated from retrieval accuracy in Amnestic Mild Cognitive Impairment (aMCI). However, the literature on this question contains variable and conflicting results, likely because of differences in experimental conditions.

Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns.

Cancer survivors have lingering cognitive problems, however the anatomical basis for these problems has yet to be fully elucidated. Clinical studies as well as animal models of chemotherapy have pinpointed cell and volume loss to the hippocampus, however, few studies have performed shape analysis of the hippocampus on cancer survivors. This study used high-dimensional deformation mapping analysis to test whether localized hippocampal deformation differs in breast cancer survivors who received adjuvant chemotherapy coupled with hormone blockade therapy, and if deformation was related to subjective self-reported concerns and cognitive performance.

Reduced prefrontal activation during working and long-term memory tasks and impaired patient-reported cognition among cancer survivors postchemotherapy compared with healthy controls.

Background: Patients who receive adjuvant chemotherapy have reported cognitive impairments that may last for years after the completion of treatment. Working memory-related and long-term memory-related changes in this population are not well understood. The objective of this study was to demonstrate that cancer-related cognitive impairments are associated with the under recruitment of brain regions involved in working and recognition memory compared with controls.

Recognition during recall failure: Semantic feature matching as a mechanism for recognition of semantic cues when recall fails.

Research suggests that a feature-matching process underlies cue familiarity-detection when cued recall with graphemic cues fails. When a test cue (e.g.

Hippocampal contribution to implicit configuration memory expressed via eye movements during scene exploration.

Although hippocampus unequivocally supports explicit/declarative memory, fewer findings have demonstrated its role in implicit expressions of memory. We tested for hippocampal contributions to an implicit expression of configural/relational memory for complex scenes using eye-movement tracking during functional magnetic resonance imaging (fMRI) scanning. Participants studied scenes and were later tested using scenes that resembled study scenes in their overall feature configuration but comprised different elements.

Associative Recognition Memory Awareness Improved by Theta-Burst Stimulation of Frontopolar Cortex.

Neuroimaging and lesion studies have implicated specific prefrontal cortex locations in subjective memory awareness. Based on this evidence, a rostrocaudal organization has been proposed whereby increasingly anterior prefrontal regions are increasingly involved in memory awareness. We used theta-burst transcranial magnetic stimulation (TBS) to temporarily modulate dorsolateral versus frontopolar prefrontal cortex to test for distinct causal roles in memory awareness.

Targeted enhancement of cortical-hippocampal brain networks and associative memory.

The influential notion that the hippocampus supports associative memory by interacting with functionally distinct and distributed brain regions has not been directly tested in humans. We therefore used targeted noninvasive electromagnetic stimulation to modulate human cortical-hippocampal networks and tested effects of this manipulation on memory. Multiple-session stimulation increased functional connectivity among distributed cortical-hippocampal network regions and concomitantly improved associative memory performance.

Connections between mechanisms for anosognosia and implicit memory.

Mograbi and Morris review work highlighting an interesting phenomenon whereby individuals are explicitly anosognosic for their deficits despite intact expression of implicit awareness. Parallels exist between this phenomenon and recent cognitive neuroscience findings demonstrating intact memory test performance despite unawareness of performance. We discuss these parallels with regard to the proposed CAM model.

Intuitively detecting what is hidden within a visual mask: familiar-novel discrimination and threat detection for unidentified stimuli.

Recognition without identification is the finding that, among recognition test items that go unidentified (as when a word is unidentified from a fragment), participants can discriminate those that were studied from those that were unstudied. In the present study, we extended this phenomenon to the more life-like situation of discriminating known from novel stimuli. Pictures of famous and nonfamous faces (Exp.

Recall versus familiarity when recall fails for words and scenes: the differential roles of the hippocampus, perirhinal cortex, and category-specific cortical regions.

This fMRI study examined recall and familiarity for words and scenes using the novel recognition without cued recall (RWCR) paradigm. Subjects performed a cued recall task in which half of the test cues resembled studied items (and thus were familiar) and half did not. Subjects also judged the familiarity of the cue itself.

Familiarity from the configuration of objects in 3-dimensional space and its relation to déjà vu: a virtual reality investigation.

Déjà vu is the striking sense that the present situation feels familiar, alongside the realization that it has to be new. According to the Gestalt familiarity hypothesis, déjà vu results when the configuration of elements within a scene maps onto a configuration previously seen, but the previous scene fails to come to mind. We examined this using virtual reality (VR) technology.

When word identification fails: ERP correlates of recognition without identification and of word identification failure.

Recognition without identification (RWI) refers to people's ability to discriminate studied from unstudied items when the items themselves fail to be identified, as when people fail to identify words from fragments. We sought to identify the ERP correlates of word fragment RWI in an effort to better understand its underlying mechanisms; in so doing, we also examined the ERP correlates of word identification failure vs. success.

Can deja vu result from similarity to a prior experience? Support for the similarity hypothesis of deja vu.

The strange feeling of having been somewhere or done something before--even though there is evidence to the contrary--is called déjà vu. Although déjà vu is beginning to receive attention among scientists (Brown, 2003, 2004), few studies have empirically investigated the phenomenon. We investigated the hypothesis that déjà vu is related to feelings of familiarity and that it can result from similarity between a novel scene and that of a scene experienced in one's past.