Impact of subchronic administration of piperazine citrate on the electrocardiogram of the rat.

The effect of piperazine citrate on the electrocardiogram of the rat after treatment with piperazine citrate at 30, 60, and 100 mg/kg body weight for 16 weeks was investigated. The results were compared with a control group. There was prolongation of P-R, Q-Tc, and J-T intervals, whereas the QRS interval remained virtually unchanged.