Social Disengagement in Post-Pandemic China: A Translation, Validation and Cross-Cultural Comparison of the Pandemic Disengagement Syndrome Scale.

Background: In contrast to abundant research on the various acute mental effects of COVID-19, the long-term influences of the pandemic are still underexplored in China owing to the paucity of assessment tools. The Pandemic Disengagement Syndrome Scale (PDSS) assesses people's social disengagement as a lasting psychological consequence in Western countries during the post-COVID-19 pandemic era. However, its generalizability across cultures is untested.

Trajectories of depressive symptoms and subjective well-being before and after the onset of the COVID-19 pandemic: Two six-year longitudinal studies.

Previous research investigated the trajectories of mental health and well-being during and after the onset of the COVID-19 pandemic. However, less is known about the trajectories of mental health and well-being before, during, and two years after the onset of the pandemic. The aim of the current study was to investigate the trajectory of depression symptoms and subjective well-being (i.

Intratumoral Heterogeneity Assessment of the Extracellular Bone Matrix and Immune Microenvironment in Osteosarcoma Using Digital Imaging to Predict Therapeutic Response.

The assessment of chemotherapy response in osteosarcoma (OS) based on the average percentage of viable cells is limited, as it overlooks the spatial heterogeneity of tumor cell response (foci of resistant cells), immune microenvironment, and bone microarchitecture. Despite the resulting positive classification for response to chemotherapy, some patients experience early metastatic recurrence, demonstrating that our conventional tools for evaluating treatment response are insufficient. We studied the interactions between tumor cells, immune cells (lymphocytes, histiocytes, and osteoclasts), and bone extracellular matrix (ECM) in 18 surgical resection samples of OS using multiplex and conventional immunohistochemistry (IHC: CD8, CD163, CD68, and SATB2), combined with multiscale characterization approaches in territories of good and poor response (GRT/PRT) to treatment.

Adaptive and maladaptive pathways of COVID-19 worry on well-being: A cross-national study.

Objective: In a preregistered study, we examined whether worries about COVID-19 are simultaneously linked with enhanced well-being through social interaction and with reduced well-being through depression symptoms.

Method: In August 2020, census-matched participants from high- and low-prevalence regions in the United States and Italy (N = 857) completed assessments of COVID-19 worry, social interaction, depression symptoms, and well-being.

Results: Worries about COVID-19 predicted both more social interaction and more depression (ps < 0.

Midfacial toddler excoriation syndrome (MiTES): case series, diagnostic criteria and evidence for a pathogenic mechanism.

Background: PRDM12 polyalanine tract expansions cause two different disorders: midfacial toddler excoriation syndrome (MiTES; itch with normal pain sensation associated with 18 homozygous alanines (18A); and congenital insensitivity to pain (CIP) with normal itch associated with 19 homozygous alanines (19A). Knowledge of the phenotype, genotype and disease mechanism of MiTES is incomplete. Why 18A vs.

Multicenter Study of Long-Term Outcomes and Quality of Life in PHACE Syndrome after Age 10.

Objective: To characterize long-term outcomes of PHACE syndrome.

Study Design: Multicenter study with cross-sectional interviews and chart review of individuals with definite PHACE syndrome ≥10 years of age. Data from charts were collected across multiple PHACE-related topics.

Media exposure related to COVID-19 is associated with worse mental health consequences in the United States compared to Italy.

Background: Prolonged media exposure after collective crises is widely shown to have adverse effects on people's mental health. Do these effects show variation across different countries? In the present study, we compared the link between media exposure related to COVID-19 and mental health-related outcomes in the United States and Italy, two countries with high levels of early COVID-19 prevalence.

Method: Participants matched on age and gender in the United States ( = 415) and Italy (= 442) completed assessments of media exposure, stress, anxiety, COVID-19 worry, and other variables shortly after the first wave of infections in 2020.

Disruptions in self-regulatory processes predict depression and sleep disturbance in bereaved young adults.

Losing a loved one is both common and profoundly stressful for young adults. Little research has examined the longitudinal course of post-loss cognitive processing, depression, and sleep difficulties. Further, little is known about the context of other stressors or the role of individual regulatory resources, such as attentional regulation, that might determine whether loss-related cognitive processing reduces distress.

Happiness before and during the COVID-19 pandemic in Italy: A population-based longitudinal study.

The aims of the present study were to investigate (1) whether the COVID-19 pandemic and the restrictive measures to control its spread were associated with changes in happiness before and after the pandemic and (2) whether household size, living with a partner/spouse, living with at least one son/daughter, financial support, income loss, and job loss following the pandemic were associated with happiness after controlling for previous levels of happiness. We use data from the Italian Survey on Household Income and Wealth (SHIW). Specifically, we used longitudinal data from 2283 respondents who participated in the SHIW 2016 and SHIW 2020.

Social and behavioral consequences of the COVID-19 pandemic: Validation of a Pandemic Disengagement Syndrome Scale (PDSS) in four national contexts.

The aim of the present study was to develop and validate a self-report measure that investigates people's general disengagement after the acute phases of the pandemic. Across three studies, we examined the psychometric features of the Pandemic Disengagement Syndrome Scale (PDSS) in four national contexts. In Study 1, we developed the instrument and investigated the factorial structure, internal consistency, measurement invariance across gender and countries (the United States and Italy), and discriminant validity.

Contribution of risk and resilience factors to anxiety trajectories during the early stages of the COVID-19 pandemic: A longitudinal study.

The COVID-19 pandemic, and the response of governments to mitigate the pandemic's spread, resulted in exceptional circumstances that comprised a major global stressor, with broad implications for mental health. We aimed to delineate anxiety trajectories over three time-points in the first 6 months of the pandemic and identify baseline risk and resilience factors that predicted anxiety trajectories. Within weeks of the pandemic onset, we established a website (covid19resilience.

Acute Genital Ulceration After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination and Infection.

Reactive, nonsexually related acute genital ulceration, also known as Lipschütz ulcer, is a nonsexually related ulceration involving the vulva, most commonly affecting girls and adolescent women in response to infection. Herein, we describe 3 female patients with acute genital ulceration occurring after severe acute respiratory syndrome coronavirus 2 vaccination or natural infection.