Publications by authors named "Anthony M Cruz"
Retinoblastoma is the most common eye cancer in children and is fatal if left untreated. Over the past three decades, chemotherapy has become the mainstay of eye-sparing treatment. Nevertheless, chemoresistance continues to represent a major challenge leading to ocular and systemic toxicity, vision loss, and treatment failure.
View Article and Find Full Text PDFUveal melanoma (UM) is the most common primary cancer of the eye and is associated with a high rate of metastatic death. UM can be stratified into two main classes based on metastatic risk, with class 1 UM having a low metastatic risk and class 2 UM having a high metastatic risk. Class 2 UM have a distinctive genomic, transcriptomic, histopathologic, and clinical phenotype characterized by biallelic inactivation of the tumor-suppressor gene, an immune-suppressive microenvironment enriched for M2-polarized macrophages, and poor response to checkpoint-inhibitor immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Scientists have made cool new tools that help study different parts of tumors by looking at tiny pieces of DNA and RNA.
- They created a tool called Uphyloplot2 that makes it easier to see how different parts of a tumor are related using special graphs.
- You can find and use Uphyloplot2 for free online to help understand tumors better!
Article Synopsis
- Single-cell RNA sequencing (scRNA-seq) helps scientists study individual cells by looking at their gene activity.
- Techniques like UMAP and tSNE make it easier to visualize and group these cells based on their similarities.
- PieParty is a new tool that changes how we see this data, using pie charts for each cell to show information about multiple genes at once, making it easier to understand.