Publications by authors named "Anthony Lteif"
Unveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: Insights.
Curr Res Pharmacol Drug Discov
October 2024
Article Synopsis
- The study evaluates two platinum (IV) complexes, P-PENT and P-HEX, for their effectiveness against skin cancer, showing strong cytotoxic effects on HaCaT-II-4 cells while being less harmful to mesenchymal stem cells.
- The complexes trigger intrinsic apoptosis through key biochemical pathways, increasing apoptotic markers and reactive oxygen species, suggesting they induce cancer cell death.
- In a mouse model, both complexes significantly inhibited tumor growth with lower doses than those used for traditional treatments like cisplatin, indicating they might be safer and more effective options for skin cancer therapy.
The growing interest in the therapeutic potential of cannabidiol (CBD) has led to the need for effective and reliable delivery methods that overcome its low oral absorption. Zeolites, a class of porous nanoparticles, offer unique advantages as drug carriers due to their high surface area and adjustable pore size. In this study, a zeolite-based drug delivery system was developed for the encapsulation of CBD.
View Article and Find Full Text PDFEthnopharmacological Relevance: The Cannabis sativa L. ssp. indica (Lam.
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