Publications by authors named "Anthony Lebras"

Article Synopsis
  • COVID-19 patients with acute ischemic stroke (AIS) exhibit thrombi that are rich in neutrophils and contain neutrophil extracellular traps (NETs), but lack the virus's spike protein.
  • A study comparing AIS thrombi from COVID-19 and non-COVID-19 patients found that both types displayed similar resistance to thrombolysis when treated with tissue-type plasminogen (tPA).
  • Adding DNase 1 enhanced the thrombolytic process for both groups, suggesting that COVID-19 does not affect NET content or the thrombi's resistance to fibrinolysis, which could help in treating such patients.
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Background And Purpose: Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated the incidence, risk factors, and clinical implications of thrombectomy complications in daily clinical practice.

Methods: We used data from the ongoing prospective multicenter observational Endovascular Treatment in Ischemic Stroke Registry in France.

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Background And Purpose: The influence of prior antiplatelet therapy (APT) uses on the outcomes of patients with acute ischemic stroke treated with endovascular therapy is unclear. We compared procedural and clinical outcomes of endovascular therapy in patients on APT or not before stroke onset.

Methods: We analyzed 2 groups from the ongoing prospective multicenter Endovascular Treatment in Ischemic Stroke registry in France: patients on prior APT (APT+) and patients without prior APT (APT-) treated by endovascular therapy, with and without intravenous thrombolysis.

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A correlation between the susceptibility vessel sign (SVS) and red thrombi has been identified in MRI. We hypothesized that the Embotrap allow better retrieving of SVS+ thrombi. The AdaptatiVe Endovascular strategy to the CloT MRI in large intracranial vessel Occlusion (VECTOR) trial is a multicenter, prospective and randomized study designed to compare a first-line strategy combining Embotrap added to contact aspiration (CA) versus CA alone in patients with SVS+ occlusions.

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