Background: Studies are limited regarding the role of intersectional social determinants of health in asymptomatic Alzheimer's disease neuropathology (ADNP).
Method: We analyzed data on 3,107 participants in the National Alzheimer's Coordinating Center's Neuropathology Dataset who had a visit ≤24 months before autopsy and confirmed ADNP (moderate to frequent neuritic plaques and Braak Stage III-VI). Groups were defined based on the presence (symptomatic ADNP, n = 2,956) or absence (asymptomatic ADNP, n = 151) of an MCI/dementia diagnosis at the final visit before death.
Background: Women comprise approximately two-thirds of Alzheimer's disease cases.
Objective: This is the first known study to investigate the role of intersectionality between gender and other social determinants of health (SDOH) in the presentation of cognitive symptoms (i.e.