Publications by Anthony J Demaggio

Publications by authors named "Anthony J Demaggio"

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Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors.

Wilna J Moree Phyllis Goldman Anthony J Demaggio Erik Christenson Dan Herendeen

Bioorg Med Chem Lett

September 2008

A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.

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